Reed Sternberg Cells

However those cells that have an imbalance in pro and anti apoptotic proteins ratio could represent a transforming event rescuing pre apoptotic gc b cells from apoptotic stimuli and finally could give rise to hodgkin and reed sternberg cells they described bcl 2 and bak cytoplasmic expression in 83 3 and 92 per cent of the cases together with p53 nuclear expression 89 9 per cent of the cases.

Reed sternberg cells.

They are large often multinucleated with a peculiar morphology and an unusual immunophenotype that does not resemble any normal cell in the body. Nci s dictionary of cancer terms provides easy to understand definitions for words and phrases related to cancer and medicine. More recently they have also been reported expressing t cell markers while lacking b cell markers. Reed sternberg like cells in t cell lymphomas typically present with a b cell immunophenotype.

Reed sternberg cells have an active jak stat signaling pathway the major pathway for cytokine signaling. Reed sternberg cells also known as lacunar histiocytes for certain types are distinctive giant cells found with light microscopy in biopsies from individuals with hodgkin lymphoma they are usually derived from b lymphocytes classically considered crippled germinal center b cells in the vast majority of cases the immunoglobulin genes of reed sternberg cells have undergone both v d j. These are found on the surface of the reed sternberg cells in classic hodgkin lymphoma chl. This pathway is presumably activated in reed sternberg cells in a paracrine and autocrine fashion but also through genetic lesions see below.

A doctor can tell the difference between hodgkin s lymphoma and non hodgkin s lymphoma by examining the cancer cells under a microscope. Tumor component reed sternberg cell typical and variants and a reactive component normal mature lymphocytes eosinophils plasma cells neutrophils fibrosis and capillaries. If in examining the cells the doctor detects the presence of a specific type of abnormal cell called a reed sternberg cell the lymphoma is classified as hodgkin s. A further hallmark of reed sternberg cells is the expression and activity of multiple.

The diagnosis criteria are. Tests for other proteins may point to nodular lymphocyte predominant hodgkin lymphoma nlphl to non hodgkin lymphoma rather than hodgkin lymphoma or maybe to other diseases. Hodgkin s lymphoma is a primary malignant tumor of the lymph nodes rarely affecting the extranodal lymphoid tissue.